Iodine → 2-Chloro-1-fluoro-4-nitrobenzene

Participants

Reaction Steps

141 G of 4-fluoronitrobenzene, 11.5 g of ferric chloride and 0.6 g of iodine were charged and then heated. At a temperature of 50° to 55° C., 80 g of chlorine was blown into the liquid over 12 hours to complete the reaction. The same succeeding procedures as in Example 1 were repeated to obtain 174 g of 3-chloro-4-fluoronitrobenzene. Analytical value thereof by gas chromatography was as follows:

Provenance & Evidence