HCID 14261123, compound → HCID 14261125, compound

HRID 1199269Notes

Reaction equation

HRID 1199269 reaction equation
[N:1]([C@@H:4]([CH2:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C@H:5]1[O:10][C:8](=[O:9])[C@H:7]([CH:11]([CH3:13])[CH3:12])[CH2:6]1)=[N+:2]=[N-:3]>C(N)CCC>[CH2:4]([NH:1][C:8](=[O:9])[C@H:7]([CH:11]([CH3:13])[CH3:12])[CH2:6][C@H:5]([OH:10])[C@@H:4]([N:1]=[N+:2]=[N-:3])[CH2:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[CH2:5][CH2:6][CH3:7]

Participants

3

Reactant 1

HCID 14261123HCID 14261123, compound

Product 1

HCID 14261125HCID 14261125, compound

Reagents, catalysts & solvents 1

HCID 8007ButylamineSolvent

Procedure

24.9 g (0.09 mol) of 5(S)-azido-6-cyclohexyl-2(S)-isopropyl-4(S)-hexanolide in 250 ml of n-butylamine are boiled under reflux for 10 hours. After evaporating off the solvent, the residue is recrystallised from hexane: m.p. 100°-100.5°.

Workup

  1. temperatureunder reflux for 10 hours
  2. customAfter evaporating off the solvent
  3. customthe residue is recrystallised from hexane

Sources & evidence

ORD record
ord-d9d754a9d42944e49e9433e3eabfade8
Source dataset
uspto-grants-1990_02
Patent number
US04898977

Reaction notes

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