Ethyl trifluoroacetate → N-butan-2-yl-2,2,2-trifluoroacetamide

HRID 1199281Notes

Reaction equation

[F:1][C:2]([F:9])([F:8])[C:3]([O:5]CC)=O.[CH:10]([NH2:14])([CH2:12][CH3:13])[CH3:11]>>[CH3:11][CH:10]([NH:14][C:3](=[O:5])[C:2]([F:1])([F:8])[F:9])[CH2:12][CH3:13]

Participants

Reactant 2

HCID 9794Ethyl trifluoroacetate

HCID 24874Sec-Butylamine

Product 1

HCID 587638N-butan-2-yl-2,2,2-trifluoroacetamide

Procedure

In a procedure similar to Example 6, ethyl trifluoroacetate (295 g, 2.07 m) was reacted with sec-butylamine. The resulting amide distilled at 72.5° C./8 mm Hg and amounted to 285 g.

Workup

distillationThe resulting amide distilled at 72.5° C./8 mm Hg

Sources & evidence

ORD record: ord-bfd0e5b4fecb4b57ba407bd2eba9b164
Source dataset: uspto-grants-1990_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04899249

Reaction notes

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