Hydrochloric Acid → (trans-4-{2-[4-(3-Chloro-thiophene-2-carbonyl)-piperidin-1-yl]-ethyl}-cyclohexyl)-carbamic acid tert-butyl ester

HRID 119929Notes

Reaction equation

HRID 119929 reaction equation
[C:16]([CH3:17])([CH3:18])([CH3:19])[O:20][C:21]([NH:22][CH:23]1[CH2:24][CH2:25][CH:26]([CH2:29][CH:30]=[O:31])[CH2:27][CH2:28]1)=[O:32].[Cl:2][c:3]1[c:4]([C:8](=[O:9])[CH:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)[s:5][cH:6][cH:7]1.[ClH:1]>>[Cl:2][c:3]1[c:4]([C:8](=[O:9])[CH:10]2[CH2:11][CH2:12][N:13]([CH2:30][CH2:29][CH:26]3[CH2:25][CH2:24][CH:23]([NH:22][C:21]([O:20][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:32])[CH2:28][CH2:27]3)[CH2:14][CH2:15]2)[s:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 24720884Tert-butyl trans-4-(2-oxoethyl)cyclohexylcarbamateHCID 66627220(3-Chlorothiophen-2-yl)-piperidin-4-ylmethanone

Product 1

HCID 66627781(trans-4-{2-[4-(3-Chloro-thiophene-2-carbonyl)-piperidin-1-yl]-ethyl}-cyclohexyl)-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-37428efe0cf2499da60a1979883915d0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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