Hydrochloric Acid → HCID 13691182, compound

Participants

Reaction Steps

β-Methyl(dl)phenylalanine hydrochloride (4 g), concentrated hydrochloric acid (20 ml) and formaldehyde (6 ml) were heated with stirring in an oil bath at 100° for 3.5 h and then evaporated to dryness to give a white froth which was dissolved in water (20 ml) and the pH adjusted to 4 with 5M NaOH, under nitrogen. The reaction mixture was stored at 5° for 60 h after which a precipitated white solid was recovered by filtration, washed with a small quantity of water and dried to yield the title compound (1.965 g) m.p. >260° (decomp).

Provenance & Evidence