Hydrochloric Acid → HCID 13691182, compound

HRID 1199356Notes

Reaction equation

HRID 1199356 reaction equation
Cl.[CH3:2][CH:3]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH:4]([C:6]([OH:8])=[O:7])[NH2:5].Cl.[CH2:16]=O.[OH-].[Na+]>O>[CH3:2][CH:3]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:16][NH:5][CH:4]1[C:6]([OH:8])=[O:7]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 127435462-Amino-3-phenylbutanoic acid hydrochloride

Product 1

HCID 13691182HCID 13691182, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

β-Methyl(dl)phenylalanine hydrochloride (4 g), concentrated hydrochloric acid (20 ml) and formaldehyde (6 ml) were heated with stirring in an oil bath at 100° for 3.5 h and then evaporated to dryness to give a white froth which was dissolved in water (20 ml) and the pH adjusted to 4 with 5M NaOH, under nitrogen. The reaction mixture was stored at 5° for 60 h after which a precipitated white solid was recovered by filtration, washed with a small quantity of water and dried to yield the title compound (1.965 g) m.p. >260° (decomp).

Workup

  1. customevaporated to dryness
  2. customto give a white froth which
  3. waitThe reaction mixture was stored at 5° for 60 h
  4. filtrationafter which a precipitated white solid was recovered by filtration
  5. washwashed with a small quantity of water
  6. customdried

Sources & evidence

ORD record
ord-5e9c6fb8afb3454ea98ec5ef3b366a94
Source dataset
uspto-grants-1990_02
Patent number
US04900737

Reaction notes

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