N-Methylhydrazinecarbothioamide → 2-isonicotinoyl-N-methylhydrazinecarbothioamide

HRID 1199370Notes

Reaction equation

HRID 1199370 reaction equation
Cl.[N:2]1[CH:7]=[CH:6][C:5]([C:8](Cl)=[O:9])=[CH:4][CH:3]=1.[CH3:11][NH:12][C:13](=[S:16])[NH:14][NH2:15]>N1C=CC=CC=1>[N:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:15][NH:14][C:13]([NH:12][CH3:11])=[S:16])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 2723853N-MethylhydrazinecarbothioamideHCID 12262826Isonicotinoyl chloride hydrochloride

Product 1

HCID 28240222-isonicotinoyl-N-methylhydrazinecarbothioamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-Pyridoyl chloride hydrochloride (10.0 g, 5.62×10-2 mole) and 4-methylthiosemicarbazide (5.91 g, 5.62×10-2 mole) was stirred at room temperature in pyridine (150 ml). After stirring overnight, the pyridine was evaporated at reduced pressure and the concentrate was washed with H2O. The undissolved product was collected by filtration and dried by suction.

Workup

  1. customthe pyridine was evaporated at reduced pressure
  2. washthe concentrate was washed with H2O
  3. filtrationThe undissolved product was collected by filtration
  4. customdried by suction

Sources & evidence

ORD record
ord-faa4eff287574cd0bc6962d6ed80d068
Source dataset
uspto-grants-1990_02
Patent number
US04900743

Reaction notes

Loading…