Sodium Iodide → HCID 19866503, compound

HRID 1199403Notes

Reaction equation

HRID 1199403 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:18]3C=CC=[C:20](C)[C:19]=3S(OCCC)(=O)=O)[S:17][C:13]=2[N:12]2[C:32]([CH3:35])=[N:33][N:34]=[C:11]2[CH2:10][N:9]=1.[I-:36].[Na+]>CC(C)=O>[I:36][CH2:20][CH2:19][CH2:18][C:16]1[S:17][C:13]2[N:12]3[C:32]([CH3:35])=[N:33][N:34]=[C:11]3[CH2:10][N:9]=[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[C:14]=2[CH:15]=1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 86743748HCID 86743748, compound

Product 1

HCID 19866503HCID 19866503, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

0.6 g (0.0011 mol) of propyl 3-[4-(2-chlorophenyl)-9methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]-diazepin-2-yl]-toluenesulphonate, prepared analogously to Example 6, and a solution of 0.2 g (0.0014 mol) of anhydrous sodium iodide in 15 ml of anhydrous acetone are stirred for 2 hours at ambient temperature. After the solvent has been removed, the residue is taken up in methylene chloride/water, the organic phase is washed several times with water, then dried, the solvent is removed and in this way 0.2 g (yield 36% of theory) of the amorphous title compound are obtained.

Workup

  1. customAfter the solvent has been removed
  2. washthe organic phase is washed several times with water
  3. customdried
  4. customthe solvent is removed and in this way 0.2 g (yield 36% of theory) of the amorphous title compound
  5. customare obtained

Sources & evidence

ORD record
ord-ccca44b448df43a7bfe3826f8218e372
Source dataset
uspto-grants-1990_02
Patent number
US04900729

Reaction notes

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