HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 19866483, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| Reactant | 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]propanoic acid | HCID 13670771 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Solvent | Acetonitrile pyridine | HCID 21959178 | — |
| Product | HCID 19866483 | HCID 19866483 | — |
Reaction Steps
3 g (7.7 mmol) of 2-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]ethane-1-carboxylic acid, 0.69 g (7.7 mmol) of 2-amino-2-methylpropan-1-ol, 2,35 g (23 mmol) of triethylamine and 4.8 g of carbon tetrachloride are stirred in 15 ml of pyridine/acetonitrile (1:1) at ambient temperature. Within 2 hours a solution of 6.2 g (23.6 mmol) of triphenylphosphine in 15 ml of the above pyridine/acetonitrile mixture is added dropwise to the mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04900729 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-76738f2270694a73b36431bf066c0270 |
| Source note | uspto-grants-1990_02 |