Triethylamine → HCID 19866483, compound

HRID 1199405Notes

Reaction equation

HRID 1199405 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([CH2:18][CH2:19][C:20](O)=[O:21])[S:17][C:13]=2[N:12]2[C:23]([CH3:26])=[N:24][N:25]=[C:11]2[CH2:10][N:9]=1.[NH2:27][C:28]([CH3:32])([CH3:31])[CH2:29]O.C(N(CC)CC)C.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>N1C=CC=CC=1.C(#N)C.C(Cl)(Cl)(Cl)Cl>[CH3:29][C:28]1([CH3:32])[CH2:31][O:21][C:20]([CH2:19][CH2:18][C:16]2[S:17][C:13]3[N:12]4[C:23]([CH3:26])=[N:24][N:25]=[C:11]4[CH2:10][N:9]=[C:8]([C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[Cl:1])[C:14]=3[CH:15]=2)=[N:27]1

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 11776TriphenylphosphineHCID 118072-Amino-2-methyl-1-propanolHCID 136707713-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]propanoic acid

Product 1

HCID 19866483HCID 19866483, compound

Reagents, catalysts & solvents 2

HCID 5943Carbon TetrachlorideSolventHCID 21959178Acetonitrile pyridineSolvent2×

Procedure

3 g (7.7 mmol) of 2-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]ethane-1-carboxylic acid, 0.69 g (7.7 mmol) of 2-amino-2-methylpropan-1-ol, 2,35 g (23 mmol) of triethylamine and 4.8 g of carbon tetrachloride are stirred in 15 ml of pyridine/acetonitrile (1:1) at ambient temperature. Within 2 hours a solution of 6.2 g (23.6 mmol) of triphenylphosphine in 15 ml of the above pyridine/acetonitrile mixture is added dropwise to the mixture.

Sources & evidence

ORD record
ord-76738f2270694a73b36431bf066c0270
Source dataset
uspto-grants-1990_02
Patent number
US04900729

Reaction notes

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