反应详情

To a mixture of 200 mg (0.850 m mol) of 7,8-dihydro-6,6-dimethyl-7-hydroxy-8-amino-6H-pyrano [2,3-f] benzo-2,1,3-oxadiazole and 20 ml of dichloromethane were added 68 mg (0.935 m mol) of methylisothiocyanate with stirring at the room temperature, followed by stirring for 23 hours. The precipitated crystals were separated by filter to obtain 122 mg of the intended compound as colorless crystals. (yield: 47%)

1. stirringby stirring for 23 hours
2. customThe precipitated crystals were separated
3. filtrationby filter