HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl isothiocyanate → 7,8-dihydro-6,6-dimethyl-7-hydroxy-8-methylthioureido-6H-pyrano[2,3-f]benzo-2,1,3-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | (+)-7,8-dihydro-6,6-dimethyl-7-hydroxy-8-amino-6H-pyrano[2,3-f]benz-2,1,3-oxadiazole | HCID 11107308 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7,8-dihydro-6,6-dimethyl-7-hydroxy-8-methylthioureido-6H-pyrano[2,3-f]benzo-2,1,3-oxadiazole | HCID 14627721 | 47% |
Reaction Steps
To a mixture of 200 mg (0.850 m mol) of 7,8-dihydro-6,6-dimethyl-7-hydroxy-8-amino-6H-pyrano [2,3-f] benzo-2,1,3-oxadiazole and 20 ml of dichloromethane were added 68 mg (0.935 m mol) of methylisothiocyanate with stirring at the room temperature, followed by stirring for 23 hours. The precipitated crystals were separated by filter to obtain 122 mg of the intended compound as colorless crystals. (yield: 47%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04900752 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-050e566bbf8f4e23b32fe78d519f4b6b |
| Source note | uspto-grants-1990_02 |