Urea → 2(1H)-Pyrimidinone, tetrahydro-1,3-diethyl-

HRID 1199474Notes

Reaction equation

HRID 1199474 reaction equation
[CH2:1]([NH:3][CH2:4][CH2:5][CH2:6][NH:7][CH2:8][CH3:9])[CH3:2].[CH2:10]([NH:13][CH2:14][CH2:15][CH2:16][NH:17][CH2:18][CH2:19][CH3:20])[CH2:11][CH3:12].N[C:22](N)=[O:23]>>[CH2:1]([N:3]1[CH2:4][CH2:5][CH2:6][N:7]([CH2:8][CH3:9])[C:22]1=[O:23])[CH3:2].[CH2:18]([N:17]1[CH2:16][CH2:15][CH2:14][N:13]([CH2:10][CH2:11][CH3:12])[C:22]1=[O:23])[CH2:19][CH3:20]

Participants

5

Reactant 3

HCID 1176UreaHCID 82334N,N'-Diethylpropane-1,3-diamineHCID 3030853HCID 3030853, compound

Product 2

HCID 991362(1H)-Pyrimidinone, tetrahydro-1,3-diethyl-HCID 991372(1H)-Pyrimidinone, tetrahydro-1,3-dipropyl-

Procedure

Further, a process has been known wherein N,N'-diethyl-1,3-propanediamine or N,N'-dipropyl-1,3-propanediamine is reacted with urea to obtain 1,3-diethyltetrahydro-2(1H)-pyrimidinone or tetrahydro-1,3-dipropyl-2(1H)-pyrimidinone with a yield of 64.0% or 21.5%, respectively (J. Med. Chem., vol. 14, page 140 (1971)). These processes are also commercially unsatisfactory due to the low yields of the objective products.

Sources & evidence

ORD record
ord-ee7d3068a1074674a9be7d4147979618
Source dataset
uspto-grants-1990_02
Patent number
US04900820

Reaction notes

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