N(6),N(6)-Dimethyladenine → 9-(2-Chloro-6-fluorobenzyl)-6-dimethylaminopurine

HRID 1199476Notes

Reaction equation

HRID 1199476 reaction equation
[CH3:1][N:2]([CH3:12])[C:3]1[N:11]=[CH:10][N:9]=[C:8]2[C:4]=1[NH:5][CH:6]=[N:7]2.[Cl:13][C:14]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:15]=1[CH2:16]Cl>>[Cl:13][C:14]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:15]=1[CH2:16][N:7]1[CH:6]=[N:5][C:4]2[C:8]1=[N:9][CH:10]=[N:11][C:3]=2[N:2]([CH3:12])[CH3:1]

Participants

3

Reactant 2

HCID 3134N(6),N(6)-DimethyladenineHCID 1086751-Chloro-2-(chloromethyl)-3-fluorobenzene

Product 1

HCID 1298029-(2-Chloro-6-fluorobenzyl)-6-dimethylaminopurine

Procedure

Employing N6,N6 -dimethyladenine prepared in Example 17 and 2-chloro-6-fluorobenzyl chloride, the same procedures as in Example 39, (1) were repeated to give a crude 9-(2-chloro-6-fluorobenzyl)-N6, N6 -dimethyladenine, in which the purity was 73.1% by weight and the content of the 3-isomer was 26.9% by weight.

Sources & evidence

ORD record
ord-5b23e40cd1504488ac1410604cad6303
Source dataset
uspto-grants-1990_02
Patent number
US04900826

Reaction notes

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