反应详情

A 50 ml portion of dimethylformamide dimethylacetal was added to 25 g of solid β-oxo-2-furanepropanenitrile. This exothermic reaction produced yellow crystals. After one hour the volatiles were removed under reduced pressure and the residue was dissolved in methylene chloride. This solution was passed through a short pad of hydrous magnesium silicate. The eluate was refluxed with the gradual addition of hexane to the point of turbidity. Cooling and filtration gave 35.2 g of the desired compound, mp 117°-125° C.

1. customThis exothermic reaction
2. customproduced yellow crystals
3. customAfter one hour the volatiles were removed under reduced pressure
4. dissolutionthe residue was dissolved in methylene chloride
5. temperatureThe eluate was refluxed with the gradual addition of hexane to the point of turbidity
6. temperatureCooling
7. filtrationfiltration