Hydrochloric Acid → 6-Chloro-4,5-dihydro-4-methyl-5-oxo-imidazo(1,5-a)quinazoline-3-carboxylic acid
Reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:21])[N:5]([CH3:20])[C:6]1[N:7]2[CH:12]=[N:13][C:14]=1[C:15]([O:17]CC)=[O:16].O.[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:21])[N:5]([CH3:20])[C:6]1[N:7]2[CH:12]=[N:13][C:14]=1[C:15]([OH:17])=[O:16]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
Ethyl 6-chloro-4,5-dihydro-4-methyl-5-oxo-imidazo(1,5-a)-quinazoline-3-carboxylate (2.27 g,7.4 mmol) in a mixture of 50 ml of ethanol, 25 ml of water and 4.6 ml of 4M aqueous sodium hydroxide was refluxed for 1 h. Then the mixture was cooled to 0° C. and neutralized by addition of 4.6 ml of 4M hydrochloric acid. The precipitate was filtered off, rinsed with water and dried to give 2.1 g (100%) of 6-chloro-4,5-dihydro-4-methyl-5-oxo-imidazo(1.5-a)quinazoline-3-carboxylic acid.
Workup
- temperaturewas refluxed for 1 h
- filtrationThe precipitate was filtered off
- washrinsed with water
- customdried
Sources & evidence
- ORD record
- ord-c7e6c9133d0a4d7db9536178fd5751cf
- Source dataset
- uspto-grants-1990_02
- Patent number
- US04902686
Reaction notes
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