Tetraethyl methylenediphosphonate → HCID 54300254, compound

HRID 1199671Notes

Reaction equation

O=[C:2]1[CH2:11][CH2:10][CH:9]2[CH:4]([CH2:5][CH2:6][N:7]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:8]2[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:3]1.[CH2:24]([O:26][P:27]([CH2:32]P(=O)(OCC)OCC)(=[O:31])[O:28][CH2:29][CH3:30])[CH3:25]>>[CH2:24]([O:26][P:27]([CH:32]=[C:2]1[CH2:11][CH2:10][CH:9]2[CH:4]([CH2:5][CH2:6][N:7]([C:17]([O:19][C:20]([CH3:22])([CH3:23])[CH3:21])=[O:18])[CH:8]2[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:3]1)([O:28][CH2:29][CH3:30])=[O:31])[CH3:25]

Participants

Reactant 2

HCID 15455Tetraethyl methylenediphosphonate

HCID 19865452HCID 19865452, compound

Product 1

HCID 54300254HCID 54300254, compoundYield 91%

Procedure

Following the preparation of Example 3A above, 2.0 g of ethyl decahydro-6-oxo-2-t-butoxycarbonyl-1-isoquinoline carboxylate were treated with 2.6 g of methylene diphosphonic acid tetraethyl ester to provide 2.57 g of the desired subtitled intermediate.

Sources & evidence

ORD record: ord-ecbbaa7ab3ca4b9083fc188a7ad26f40
Source dataset: uspto-grants-1990_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04902695

Reaction notes

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