Ethanol → HCID 19865487, compound

HRID 1199679Notes

Reaction equation

HRID 1199679 reaction equation
[C:1]1([S:7]([NH:10][C:11]2[C:12]([CH2:17][CH2:18]CC#N)=[N:13][CH:14]=[CH:15][CH:16]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:22].[Na+].[CH2:24]([OH:26])[CH3:25]>>[C:1]1([S:7]([NH:10][C:11]2[C:12]([CH2:17][CH2:18][CH2:25][C:24]([OH:22])=[O:26])=[N:13][CH:14]=[CH:15][CH:16]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 14989652HCID 14989652, compound

Product 1

HCID 19865487HCID 19865487, compound

Procedure

A solution of 3-benzenesulphonamido-2-(3-cyanopropyl)pyridine (5.22 g) in ethanol (100 ml) and 15% w/v sodium hydroxide solution (50 ml) was refluxed for 6 hours. The pH of the solution was adjusted to pH=4 when a white solid precipitated from the solution. The solid was collected by filtration and recrystallised from ethanol to give the title compound (3.34 g) as white needles. m.p. 156°-157° C.

Workup

  1. temperaturewas refluxed for 6 hours
  2. customprecipitated from the solution
  3. filtrationThe solid was collected by filtration
  4. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-319d75f9aaad4d3a8da6ec0684f5c02f
Source dataset
uspto-grants-1990_02
Patent number
US04902698

Reaction notes

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