Hydrochloric Acid → HCID 14989662, compound

HRID 1199687Notes

Reaction equation

HRID 1199687 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH2:19][CH2:20][C:21]([O:23]C)=[O:22])=[N:16][CH:17]=2)(=[O:11])=[O:10])=[CH:4][CH:3]=1.[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][S:9]([C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[N:16][CH:17]=2)(=[O:11])=[O:10])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14989660HCID 14989660, compound

Product 1

HCID 14989662HCID 14989662, compoundYield 65.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
5 °C

Procedure

A solution of methyl 4-[5-(4-chlorophenylsulphamoyl)pyrid-2-yl]butanoate (0.8 g), 10% w/v sodium hydroxide solution (5 ml) in ethanol (15 ml) was stirred for 1 hour. The solution was acidified with dilute hydrochloric acid (pH 3) and cooled to 5° C. The white precipitate was collected and recrystallised from ethanol to give the title compound (0.504 g) as prisms. m.p. 150°-152° C.

Workup

  1. customThe white precipitate was collected
  2. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-4141b7cde5f24bee91f951356a43bce3
Source dataset
uspto-grants-1990_02
Patent number
US04902698

Reaction notes

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