反应详情

A mixture of 1.60 g of 3-nitrobenzyl chloride, 1.3 g of 2-hydroxymethylbenzothiazole and 0.54 of potassium carbonate in 20 ml of acetone was stirred at room temperature for 1.5 hours and then refluxed for 30 minutes. After evaporation of acetone under reduced pressure, the residue was dissolved in ethyl acetate, washed with water and dried over magnesium sulfate, followed by evaporation of the solvent under reduced pressure. The residue was purified through a silica gel column chromatography by use of ethyl ether-n-hexane to obtain 1.7 g (yield 73%) of the title compound.

1. temperaturerefluxed for 30 minutes
2. customAfter evaporation of acetone under reduced pressure
3. dissolutionthe residue was dissolved in ethyl acetate
4. washwashed with water
5. dry with materialdried over magnesium sulfate
6. customfollowed by evaporation of the solvent under reduced pressure
7. customThe residue was purified through a silica gel column chromatography by use of ethyl ether-n-hexane