HCID 7986269, compound → 2-[2-(3-Hydroxyphenyl)ethyl]benzothiazole

HRID 1199695Notes

Reaction equation

HRID 1199695 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)/[CH:5]=[CH:6]/[C:7]1[S:8][C:9]2[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=2[N:11]=1>C(O)C.[C].[Pd]>[OH:1][C:2]1[CH:3]=[C:4]([CH2:5][CH2:6][C:7]2[S:8][C:9]3[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=3[N:11]=2)[CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 1

HCID 7986269HCID 7986269, compound

Product 1

HCID 140511612-[2-(3-Hydroxyphenyl)ethyl]benzothiazoleYield 92%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A mixture of 6.0 g of 2-(trans-3-hydroxystyryl) benzothiazole and 0.5 g of 5% palladium-carbon in 80 ml of ethanol was stirred under hydrogen gas stream under normal pressure at 50° to 60° C. for 3 hours. After completion of the reaction, the catalyst was filtered off and the filtrate was evaporated under reduced pressure to obtain 5.5 g (yield 92%) of the title compound as pale gray crystals.

Workup

  1. customAfter completion of the reaction
  2. filtrationthe catalyst was filtered off
  3. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-5681bb550444475ca7f3f7878af95cdd
Source dataset
uspto-grants-1990_02
Patent number
US04902700

Reaction notes

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