HCID 54070531, compound → HCID 14051166, compound

HRID 1199700Notes

Reaction equation

HRID 1199700 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[CH:5]=[CH:6][C:7]1[S:8][C:9]([CH3:14])=[C:10]([CH2:12][CH3:13])[N:11]=1.[H][H]>[C].[Pd].C(O)C>[NH2:1][C:2]1[CH:3]=[C:4]([CH2:5][CH2:6][C:7]2[S:8][C:9]([CH3:14])=[C:10]([CH2:12][CH3:13])[N:11]=2)[CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 2

HCID 54070531HCID 54070531, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14051166HCID 14051166, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

An amount of 1.0 g of 2-(3-aminostyryl)-4-ethyl-5-methylthiazole and 200 mg of 5% palladium-carbon were added to 20 ml of ethanol and catalytic reduction was carried out in a hydrogen gas atmosphere at room temperature and normal pressure for 12 hours. After the reaction mixture was filtered, the solvent was evaporated under reduced pressure to give 0.90 g (yield 90%) of the title compound as pale yellow crystals.

Workup

  1. filtrationAfter the reaction mixture was filtered
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-ef96e926a1984d2298f1cdc66a0f23a8
Source dataset
uspto-grants-1990_02
Patent number
US04902700

Reaction notes

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