Methanol → HCID 86743765, compound

HRID 1199706Notes

Reaction equation

HRID 1199706 reaction equation
CO.[CH3:3][NH:4][CH2:5][C@@H:6]([C@H:8]([C@@H:10]([C@@H:12]([CH2:14][OH:15])[OH:13])[OH:11])[OH:9])[OH:7].[C:16]([C@H:19]1[CH2:24][CH2:23][CH2:22][CH2:21][C@H:20]1[C:25]([NH:27][C:28]1[CH:29]=[C:30]([CH:42]=[CH:43][CH:44]=1)/[CH:31]=[CH:32]/[C:33]1[S:34][C:35]2[CH:41]=[CH:40][CH:39]=[CH:38][C:36]=2[N:37]=1)=[O:26])([OH:18])=[O:17]>O>[CH3:3][NH:4][CH2:5][C@@H:6]([C@H:8]([C@@H:10]([C@@H:12]([CH2:14][OH:15])[OH:13])[OH:11])[OH:9])[OH:7].[C:16]([C@H:19]1[CH2:24][CH2:23][CH2:22][CH2:21][C@H:20]1[C:25]([NH:27][C:28]1[CH:29]=[C:30]([CH:42]=[CH:43][CH:44]=1)/[CH:31]=[CH:32]/[C:33]1[S:34][C:35]2[CH:41]=[CH:40][CH:39]=[CH:38][C:36]=2[N:37]=1)=[O:26])([OH:18])=[O:17]

Participants

5

Reactant 3

HCID 887MethanolHCID 8567N-Methyl-D-glucamineHCID 14051233HCID 14051233, compound

Product 1

HCID 86743765HCID 86743765, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Into a solvent mixture of 6 ml of methanol and 1 ml of water were added 96 mg of N-methyl-D-glucamine and 200 mg of 2-[trans-3-(cis-2-carboxycyclohexanoyl)aminostyryl]benzothiazole and the mixture was stirred at room temperature for 30 minutes. After evaporation of the solvent under reduced pressure, the crude crystals formed were recrystallized from ethanol-ethyl ether to obtain 215 mg (yield 73%) of the title compound.

Workup

  1. customAfter evaporation of the solvent under reduced pressure
  2. customthe crude crystals formed
  3. customwere recrystallized from ethanol-ethyl ether

Sources & evidence

ORD record
ord-6549b0645fff4c2bbda5a59c961e3bb7
Source dataset
uspto-grants-1990_02
Patent number
US04902700

Reaction notes

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