反应详情

The nitroxanthone from step (B) (1.55 g) was dissolved in a solution of sodium bicarbonate (0.42 g) in water (150 ml) with warming. To the solution was added 10% palladium on carbon catalyst and the solution hydrogenated at room temperature and atmospheric pressure for 4 hr, during which time hydrogen uptake was measured as 440 ml. The solution was filtered and the filtrate acidified with twice-normal hydrochloric acid solution. The amino-compound was filtered from the warmed mixture, washed well with water and dried to yield 0.98 g, mpt. 296°-297° C. with decomposition.

1. temperaturewith warming
2. customhydrogenated at room temperature
3. filtrationThe solution was filtered
4. filtrationThe amino-compound was filtered from the warmed mixture
5. washwashed well with water
6. customdried
7. customto yield 0.98 g, mpt
8. custom296°-297° C.