HCID 12371433, compound → HCID 19865838, compound

HRID 1199771Notes

Reaction equation

HRID 1199771 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[NH:13][C:12](=S)[CH2:11][N:10]=[C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])[C:8]=2[CH:22]=1)([O-:3])=[O:2].[CH2:23]([O:25][CH2:26][C:27]([NH:29][NH2:30])=O)[CH3:24]>C(O)CCC>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:27]([CH2:26][O:25][CH2:23][CH3:24])=[N:29][N:30]=[C:12]3[CH2:11][N:10]=[C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])[C:8]=2[CH:22]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 12371433HCID 12371433, compoundHCID 147502092-Ethoxyacetohydrazide

Product 1

HCID 19865838HCID 19865838, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

In the manner given in Example 1, a solution of 1,3-dihydro-7-nitro-5-(o-chlorophenyl)-2H-1,4-benzodiazepine-2-thione in n-butyl alcohol was heated to reflux with ethoxyacetic acid hydrazide to give 8-nitro-1-(ethoxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-8351b0e761ca48699101f0dfdd70709b
Source dataset
uspto-grants-1990_02
Patent number
US04902794

Reaction notes

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