HCID 19865820, compound → HCID 19865816, compound

HRID 1199774Notes

Reaction equation

HRID 1199774 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[C:8]2[C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([S:21]([CH3:24])(=[O:23])=[O:22])[CH:16]=3)=[N:10][CH2:11][C:12](=S)[NH:13][C:7]=2[CH:6]=[CH:5][CH:4]=1.[CH2:27]([O:30][CH2:31][C:32]([NH:34][NH2:35])=O)[CH2:28][CH3:29]>C(O)CCC>[F:26][C:2]([F:25])([F:1])[C:3]1[C:8]2[C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([S:21]([CH3:24])(=[O:23])=[O:22])[CH:16]=3)=[N:10][CH2:11][C:12]3[N:13]([C:32]([CH2:31][O:30][CH2:27][CH2:28][CH3:29])=[N:34][N:35]=3)[C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 19865820HCID 19865820, compoundHCID 54792666HCID 54792666, compound

Product 1

HCID 19865816HCID 19865816, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

In the manner given in Example 1, a solution of 1,3-dihydro-6-trifluoromethyl-5-[m-(methylsulfonyl)phenyl]-2H-1,4-benzodiazepine-2-thione in n-butyl alcohol was heated to reflux with propoxyacetic acid hydrazide to give 7-trifluoromethyl-1-(propoxymethyl)-6-[m-(methylsulfonyl)phenyl]-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-e792a2789bb54662ac4ef49b2e24bd11
Source dataset
uspto-grants-1990_02
Patent number
US04902794

Reaction notes

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