2-Methoxyacetohydrazide → HCID 19865805, compound

HRID 1199775Notes

Reaction equation

HRID 1199775 reaction equation
[Br:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:12]3[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=3[F:19])=[N:7][CH2:8][C:9](=S)[NH:10][C:4]=2[CH:3]=1.[CH3:22][O:23][CH2:24][C:25]([NH:27][NH2:28])=O>C(O)CCC>[Br:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:12]3[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=3[F:19])=[N:7][CH2:8][C:9]3[N:10]([C:25]([CH2:24][O:23][CH3:22])=[N:27][N:28]=3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 27595322-MethoxyacetohydrazideHCID 19865777HCID 19865777, compound

Product 1

HCID 19865805HCID 19865805, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

In the manner given in Example 1, a solution of 1,3-dihydro-8-bromo-5-(2,6-difluorophenyl)-2H-1,4-benzodiazepine-2-thione in n-butyl alcohol was heated to reflux with methoxyacetic acid hydrazide to give 9-bromo-1-(methoxymethyl)-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-33eac0f1e0b24081b6b347a3859ace30
Source dataset
uspto-grants-1990_02
Patent number
US04902794

Reaction notes

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