HCID 16641271, compound → HCID 19865766, compound

HRID 1199776Notes

Reaction equation

HRID 1199776 reaction equation
[CH2:1]([S:3]([C:5]1[C:10]2[C:11]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=3)=[N:12][CH2:13][C:14](=S)[NH:15][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4])[CH3:2].[CH:27]([O:30][CH2:31][C:32]([NH:34][NH2:35])=O)([CH3:29])[CH3:28]>C(O)CCC>[CH2:1]([S:3]([C:5]1[C:10]2[C:11]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:24])[F:25])=[CH:19][CH:18]=3)=[N:12][CH2:13][C:14]3[N:15]([C:32]([CH2:31][O:30][CH:27]([CH3:29])[CH3:28])=[N:34][N:35]=3)[C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4])[CH3:2]

Participants

4

Reactant 2

HCID 16641271HCID 16641271, compoundHCID 19865778HCID 19865778, compound

Product 1

HCID 19865766HCID 19865766, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

In the manner given in Example 1, a solution of 1,3-dihydro-6-ethylsulfinyl-5-[p-(trifluoromethyl)phenyl]-2H-1,4-benzodiazepine-2-thione in n-butyl alcohol was heated to reflux with isopropoxyacetic acid hydrazide to give 7-ethylsulfinyl-1-(isopropoxymethyl)-6-[p-(trifluoromethyl)phenyl]-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-e44cff40b7da4891b905400999a69594
Source dataset
uspto-grants-1990_02
Patent number
US04902794

Reaction notes

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