2-Hydroxyacetohydrazide → HCID 86743766, compound

HRID 1199787Notes

Reaction equation

HRID 1199787 reaction equation
C(S([C:5]1[CH:25]=[C:24](N(CC)CC)[C:8]2[C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][CH:22]=[O:23])[CH:16]=3)=[N:10][CH2:11][C:12](=S)[NH:13][C:7]=2[CH:6]=1)=O)C.OC[C:33]([NH:35][NH2:36])=O>C(O)CCC>[CH:22]([NH:21][C:17]1[CH:16]=[C:15]([C:9]2[C:8]3[CH:24]=[CH:25][CH:5]=[CH:6][C:7]=3[N:13]3[CH:33]=[N:35][N:36]=[C:12]3[CH2:11][N:10]=2)[CH:20]=[CH:19][CH:18]=1)=[O:23]

Participants

4

Reactant 2

HCID 3505362-HydroxyacetohydrazideHCID 19865780HCID 19865780, compound

Product 1

HCID 86743766HCID 86743766, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

In the manner given in Example 11, a solution of 1,3-dihydro-8-(ethylsulfinyl)-6-(diethylamino)-5-(m-formamidophenyl)-2H-1,4-benzodiazepine-2-thione and hydroxyacetic acid hydrazide in n-butylalcohol was refluxed to give 9-(ethylsulfinyl)-7-(diethylamino)-1-hydroxymethyl)-6-(m-formamidophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-aecc73d870de44a598ce08bc7f555a8a
Source dataset
uspto-grants-1990_02
Patent number
US04902794

Reaction notes

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