Glutaric anhydride → HCID 70359442, compound

HRID 1199792Notes

Reaction equation

HRID 1199792 reaction equation
[CH2:1]([S:4][C:5]1[C:15]2[N:14]3[C:16]([CH2:19][OH:20])=[N:17][N:18]=[C:13]3[CH:12]([CH3:21])[N:11]=[C:10]([C:22]3[C:27]([CH2:28][CH3:29])=[CH:26][CH:25]=[CH:24][C:23]=3[CH2:30][CH3:31])[C:9]=2[CH:8]=[CH:7][CH:6]=1)[CH2:2][CH3:3].[C:32]1(=[O:39])[O:38][C:36](=[O:37])[CH2:35][CH2:34][CH2:33]1>O>[C:32]([OH:38])(=[O:39])[CH2:33][CH2:34][CH2:35][C:36]([OH:20])=[O:37].[CH2:1]([S:4][C:5]1[C:15]2[N:14]3[C:16]([CH2:19][OH:20])=[N:17][N:18]=[C:13]3[CH:12]([CH3:21])[N:11]=[C:10]([C:22]3[C:27]([CH2:28][CH3:29])=[CH:26][CH:25]=[CH:24][C:23]=3[CH2:30][CH3:31])[C:9]=2[CH:8]=[CH:7][CH:6]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 7940Glutaric anhydrideHCID 19865829HCID 19865829, compound

Product 1

HCID 70359442HCID 70359442, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a manner similar to Example 12, a mixture of 10-propylthio-4-methyl-1-(hydroxymethyl)-6-(2,6-diethylphenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine and glutaric anhydride was heated on the water bath to give 10-propylthio-4-methyl-1-(hydroxymethyl)-6-(2,6-diethylphenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine hydrogen glutarate (ester).

Sources & evidence

ORD record
ord-f511b49c0b6f4a10bfe6c19d7a18f71f
Source dataset
uspto-grants-1990_02
Patent number
US04902794

Reaction notes

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