反应详情

Potassium t-butoxide (1.01 g) was added to a solution of ethyl amidomalonate (1.38 g) in tetrahydrofuran (38 ml) maintained at 33°. After cooling to 25°, ethyl 4-fluorocinnamate (1.50 g) was added and the mixture stirred overnight at room temperature. Brine was added, the mixture extracted with ethyl acetate (3×60 ml) and the organic solution dried and evaporated to give the crude product. This was chromatographed on silica gel, using dry ether as eluent, to give the title compound (0.92 g, 43%), m.p. 97°-99°.

1. temperaturemaintained at 33°
2. temperatureAfter cooling to 25°
3. extractionthe mixture extracted with ethyl acetate (3×60 ml)
4. customthe organic solution dried
5. customevaporated
6. customto give the crude product
7. customThis was chromatographed on silica gel