化工社化工社 化学情報印刷レポート · 研究参考用
(+/-)-trans-3-Ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione → (3S,4R)-4-(4-Fluorophenyl)-3-piperidinemethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (+/-)-trans-3-Ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione | HCID 11391819 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (3S,4R)-4-(4-Fluorophenyl)-3-piperidinemethanol | HCID 9855829 | 22% |
反応手順
Compound E1 (±)-trans-3-ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione (2.0 g) was reduced with lithium aluminium hydride (0.58 g) in refluxing tetrahydrofuran (50 ml) for 4 hours. Work up as described in Example 5 gave the title compound as a solid (0.28 g, 22%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04902801 |
| 出典データセット | uspto-grants-1990_02 |
| ORD ID | ord-7d96f019b66a45868fd24994dd9a6a7a |
| 出典メモ | uspto-grants-1990_02 |