反应详情

Five g of the compound of Example 2 was slurried in 100 ml of 50% aqueous acetone, 0.67 g of sodium hydroxide was added, and the mixture was warmed and stirred for 15 minutes. Then 10.6 g of octadecyl-trimethylammonium chloride, 50% solution, was added and the mixture was stirred overnight. It was then extracted with 100 ml of ethyl acetate, and the organic layer was washed with brine and dried with sodium sulfate and phase separation paper. The extract was then evaporated under vacuum to obtain 9.95 g of the desired product, m.p. 141°-144°. It was identified by elemental and nuclear magnetic resonance analysis.

1. temperaturethe mixture was warmed
2. stirringthe mixture was stirred overnight
3. extractionIt was then extracted with 100 ml of ethyl acetate
4. washthe organic layer was washed with brine
5. dry with materialdried with sodium sulfate and phase separation paper
6. customThe extract was then evaporated under vacuum