Hydrochloric Acid → HCID 19864338, compound

HRID 1199918Notes

Reaction equation

HRID 1199918 reaction equation
C([NH:4][C:5]1[S:21][C:8]2[CH:9]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:10][N:11]([CH3:14])[CH2:12][CH2:13][C:7]=2[CH:6]=1)(=O)C.[ClH:22]>>[ClH:22].[ClH:22].[CH3:14][N:11]1[CH2:12][CH2:13][C:7]2[CH:6]=[C:5]([NH2:4])[S:21][C:8]=2[CH:9]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19864295HCID 19864295, compound

Product 1

HCID 19864338HCID 19864338, compound

Procedure

A mixture of 2-acetamido-6-methyl-8-phenyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine (10 mg) and 5M hydrochloric acid (2.0 ml) was heated to 90° for 30 minutes. The mixture was basified and extracted with dichloromethane (2×5 ml). The extracts were dried, filtered and evaporated to a yellow oil. This was immediately converted to the title product by dissolving in ethanolic hydrogen chloride and evaporating.

Workup

  1. temperaturewas heated to 90° for 30 minutes
  2. extractionextracted with dichloromethane (2×5 ml)
  3. customThe extracts were dried
  4. filtrationfiltered
  5. customevaporated to a yellow oil
  6. dissolutionby dissolving in ethanolic hydrogen chloride
  7. customevaporating

Sources & evidence

ORD record
ord-ee361403b2c649e3988293110287b92f
Source dataset
uspto-grants-1990_02
Patent number
US04904653

Reaction notes

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