Sulfuryl chloride → HCID 19864302, compound

HRID 1199922Notes

Reaction equation

HRID 1199922 reaction equation
S(Cl)([Cl:4])(=O)=O.[ClH:6].[CH3:7][N:8]1[CH2:14][CH2:13][C:12]2[CH:15]=[CH:16][S:17][C:11]=2[CH:10]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:9]1>>[ClH:4].[Cl:6][C:16]1[S:17][C:11]2[CH:10]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:9][N:8]([CH3:7])[CH2:14][CH2:13][C:12]=2[CH:15]=1

Participants

3

Reactant 2

HCID 24648Sulfuryl chlorideHCID 19864292HCID 19864292, compound

Product 1

HCID 19864302HCID 19864302, compound

Procedure

Sulphuryl chloride (0.16 ml) was added to a stirred solution of 6-methyl-8-phenyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine hydrochloride (0.49 g free base converted to hydrochloride salt with ethanolic hydrogen chloride) at room temperature. After 2 hours the mixture was evaporated and the solid residue recrystallised twice from ethanol (5 ml) to give the title product as white crystals (m.p. 198°).

Workup

  1. customAfter 2 hours the mixture was evaporated
  2. customthe solid residue recrystallised twice from ethanol (5 ml)

Sources & evidence

ORD record
ord-4ea1a8a2b0e347e2a2962addb307330a
Source dataset
uspto-grants-1990_02
Patent number
US04904653

Reaction notes

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