反应详情

A mixture of 13.9 g of 4-amino-5-imidazolecarboxamide hydrochloride, 24.0 g of 3'-chloro-3-dimethylaminoacrylophenone (U.S. Pat. No. 4,209,621, Ex. 50) and 200 ml of glacial acetic acid was heated at reflux for 5 hours. The liquid was evaporated in vacuo to give a yellow solid. The excess acid was neutralized with saturated sodium bicarbonate solution and this mixture was filtered and the solid was washed with water and then was dried. Recrystallization from ethanol-methanol gave 10.2 g of the desired product as yellow crystals, mp 252°-254° C.

1. temperatureat reflux for 5 hours
2. customThe liquid was evaporated in vacuo
3. customto give a yellow solid
4. filtrationthis mixture was filtered
5. washthe solid was washed with water
6. customwas dried
7. customRecrystallization from ethanol-methanol