Acetic Acid → HCID 14623685, compound

HRID 1199967Notes

Reaction equation

[C-:1]#[N:2].[K+].Cl.CN(C)[CH2:7][CH:8]([CH3:24])[C:9]([C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:18]=[CH:19][C:20](=[O:23])[NH:21][N:22]=2)=[CH:13][CH:12]=1)=[O:10].C(O)(=O)C>O>[C:1]([CH2:7][CH:8]([CH3:24])[C:9]([C:11]1[CH:12]=[CH:13][C:14]([C:17]2[CH:18]=[CH:19][C:20](=[O:23])[NH:21][N:22]=2)=[CH:15][CH:16]=1)=[O:10])#[N:2]

Participants

Conditions

Temperature: 50 °C

Procedure

Potassium cyanide (0.32 g) was added to a cooled (5° C.) solution of 6-[4-(3-dimethylamino-2-methylpropionyl)phenyl]pyridazin-3(2H)-one hydrochloride (1.28 g) and acetic acid (0.25 ml) in water (30 ml). The solution was stirred for 2 hours at less than 23° C., then cooled and a further amount of potassium cyanide (0.32 g) was added. After stirring for one hour the temperature was raised to 50° C. and the reaction mixture was stirred for 2 hours to afford 6-[4-(3-cyano-2-methylpropionyl)phenyl]pyridazin-3(2H)-one (0.61 g), m.p. 196°-201° C. (dec), ν(C=N) 2240 cm-1.

Workup

temperaturecooled
stirringAfter stirring for one hour the temperature
stirringthe reaction mixture was stirred for 2 hours

Sources & evidence

ORD record: ord-74122005bd764b8e9b211b9369c08183
Source dataset: uspto-grants-1990_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04904664

Reaction notes

Loading…