反应详情

A mixture of 17.62 g (0.1 mole) of 3-amino-4-mercapto-quinoline, 150 ml of 100% formic acid and 1.5 g of sodium pyrosulfite is refluxed for 3 hours. The reaction mixture is cooled, diluted with a mixture of 800 ml of water and 40 ml of concentrated hydrochloric acid, made alkaline to pH 10 by adding a sodium hydroxide solution and extracted three times with 200 ml of benzene each. The benzene solution is evaporated. Thus 15.0 g of thiazolo[4,5-c]quinoline are obtained, m.p.: 114°-116° C., yield 80%.

1. temperatureis refluxed for 3 hours
2. temperatureThe reaction mixture is cooled
3. extractionextracted three times with 200 ml of benzene each
4. customThe benzene solution is evaporated