HCID 19864513, compound → HCID 19864521, compound

HRID 1199991Notes

Reaction equation

HRID 1199991 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][C:8]=1[N+:13]([O-])=O>C(O)C.[Ni]>[NH2:13][C:8]1[CH:9]=[N:10][CH:11]=[CH:12][C:7]=1[NH:6][CH2:5][CH2:4][CH2:3][CH2:2][OH:1]

Participants

4

Reactant 1

HCID 19864513HCID 19864513, compound

Product 1

HCID 19864521HCID 19864521, compoundYield 106.8%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

4-(4-Hyrdoxybutylamino)-3-nitropyridine (6 g) was dissolved in ethanol (60 cm3) containing Raney Ni catalyst (0.5 g) and then hydrogenated at room temperature for 3 hours under pressure (30 p.s.i.=206.8 kPa). The mixture was filtered under nitrogen and the filtrate was evaporated under vacuum to yield the crude product (5.5 g) which was used directly in the next step.

Workup

  1. filtrationThe mixture was filtered under nitrogen
  2. customthe filtrate was evaporated under vacuum

Sources & evidence

ORD record
ord-df0936c4be214fc3ac5b740d6cd5369c
Source dataset
uspto-grants-1990_02
Patent number
US04904671

Reaction notes

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