4-Amino-1-butanol → HCID 19864525, compound

Participants

Reaction Steps

2,5-Dimethyl-1,3,4-oxadiazole (3.8 g), 4-aminobutanol (3.5 g) and N-methylpyrrolidone (10 ml) were heated at 150° for 18 hours. The mixture was evaporated under high vacuum and the residue chromatographed on silica eluting with a mixture of ethyl acetate and methanol. The fractions containing the product were evaporated under vacuum to leave the title compound, (5.1 g), which was used directly.

Provenance & Evidence