4-Amino-1-butanol → HCID 19864525, compound

HRID 1199993Notes

Reaction equation

HRID 1199993 reaction equation
[CH3:1][C:2]1O[C:4]([CH3:7])=[N:5][N:6]=1.[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]>CN1CCCC1=O>[CH3:1][C:2]1[N:8]([CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[C:4]([CH3:7])=[N:5][N:6]=1

Participants

4

Reactant 2

HCID 258684-Amino-1-butanolHCID 47363912,5-dimethyl-1,3,4-oxadiazole

Product 1

HCID 19864525HCID 19864525, compoundYield 77.8%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

2,5-Dimethyl-1,3,4-oxadiazole (3.8 g), 4-aminobutanol (3.5 g) and N-methylpyrrolidone (10 ml) were heated at 150° for 18 hours. The mixture was evaporated under high vacuum and the residue chromatographed on silica eluting with a mixture of ethyl acetate and methanol. The fractions containing the product were evaporated under vacuum to leave the title compound, (5.1 g), which was used directly.

Workup

  1. customThe mixture was evaporated under high vacuum
  2. customthe residue chromatographed on silica eluting with a mixture of ethyl acetate and methanol
  3. additionThe fractions containing the product
  4. customwere evaporated under vacuum

Sources & evidence

ORD record
ord-2c839f4aff904142bcafac9adb3c4cd1
Source dataset
uspto-grants-1990_02
Patent number
US04904671

Reaction notes

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