反应详情

A mixture of 500 mg (2.4 mmol) of 5-carboxy-2-(4,5-dihydro-2-thiazolyl)-pyridine, 50 mg of 10% Pd on C and 5 g of diphenylether is refluxed for 4 h. The mixture is then diluted with methanol and the catalyst filtered off. The methanol is evaporated and some hexane added to the residue. The diphenylether dissolves and a solid is left, which is filtered off and washed with hexane. This residue is dissolved again in methanol and treated with charcoal. After evaporation of the methanol the title compound, m.p. >300°, is obtained.

1. temperatureis refluxed for 4 h
2. filtrationthe catalyst filtered off
3. customThe methanol is evaporated
4. additionsome hexane added to the residue
5. dissolutionThe diphenylether dissolves
6. waita solid is left
7. filtrationwhich is filtered off
8. washwashed with hexane
9. dissolutionThis residue is dissolved again in methanol
10. additiontreated with charcoal
11. customAfter evaporation of the methanol the title compound, m.p. >300°
12. customis obtained