Hydroxyamine hydrochloride → 1-(5-Carboxy-2-pyridinyl)-1-butanone oxime

HRID 1200032Notes

Reaction equation

HRID 1200032 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10](=O)[CH2:11][CH2:12][CH3:13])=[N:8][CH:9]=1)([OH:3])=[O:2].Cl.[NH2:16][OH:17]>N1C=CC=CC=1>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10](=[N:16][OH:17])[CH2:11][CH2:12][CH3:13])=[N:8][CH:9]=1)([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 198645601-(5-Carboxy-2-pyridinyl)-1-butanone

Product 1

HCID 1363645821-(5-Carboxy-2-pyridinyl)-1-butanone oxime

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a stirred solution of 1-(5-carboxy-2-pyridinyl)-1-butanone (2 mmol) in 20 ml of pyridine, hydroxylamine hydrochloride (4 mmol) is added. The reaction mixture is stirred at room temperature for 5 h. The solvent is distilled off and the residue crystallized from ethyl acetate; m.p. 203°-205°.

Workup

  1. distillationThe solvent is distilled off
  2. customthe residue crystallized from ethyl acetate

Sources & evidence

ORD record
ord-995a696643dd4f6eb2a1c9ad35988cf2
Source dataset
uspto-grants-1990_02
Patent number
US04904675

Reaction notes

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