HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 4-carboxy-isoquinoline N-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Isoquinoline-4-carboxylic acid | HCID 459768 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-carboxy-isoquinoline N-oxide | HCID 53706223 | — |
Reaction Steps
4-Carboxy-isoquinoline [J. Amer. Chem. Soc. 67, 1268 (1945)](10 g, 0.058 mol) is refluxed in 100 ml of acetic acid containing 13 ml of hydrogen peroxide (30%) overnight. After cooling, the solution is evaporated to dryness and the residue is purified by column chromatography (ethyl acetate/methanol/formic acid 3:2:1) to yield 4-carboxy-isoquinoline N-oxide, m.p. 280°-283°, Rf =0.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04904675 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-55f40506312d4329b1bf8e23cf4be1d9 |
| Source note | uspto-grants-1990_02 |