反应详情

4-Carboxy-isoquinoline [J. Amer. Chem. Soc. 67, 1268 (1945)](10 g, 0.058 mol) is refluxed in 100 ml of acetic acid containing 13 ml of hydrogen peroxide (30%) overnight. After cooling, the solution is evaporated to dryness and the residue is purified by column chromatography (ethyl acetate/methanol/formic acid 3:2:1) to yield 4-carboxy-isoquinoline N-oxide, m.p. 280°-283°, Rf =0.3.

1. temperatureAfter cooling
2. customthe solution is evaporated to dryness
3. customthe residue is purified by column chromatography (ethyl acetate/methanol/formic acid 3:2:1)