Water → HCID 70373314, compound

HRID 1200111Notes

Reaction equation

HRID 1200111 reaction equation
[CH:1]1[C:6]2[O:7][C:8]3[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=3[CH2:10][C:11](=O)[CH2:12][C:5]=2[CH:4]=[CH:3][CH:2]=1.O.[CH3:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>CC1C=CC=CC=1>[CH3:19][N:20]1[CH2:25][CH2:24][N:23]([C:11]2[CH2:10][C:9]3[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=3[O:7][C:6]3[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=3[CH:12]=2)[CH2:22][CH2:21]1

Participants

5

Reactant 3

HCID 962WaterHCID 531671-MethylpiperazineHCID 19864641HCID 19864641, compound

Product 1

HCID 70373314HCID 70373314, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

5H-Dibenz[b,g]oxocin-6(7H)-one (3 g) was dissolved in a mixture of methylbenzene (30 ml) and N-methylpiperazine (2.25 ml) and the solution was refluxed for sixteen hours, with water being removed via a Dean and Stark trap. The reaction mixture was then evaporated to dryness and the product re-treated, as described above, a further two times. The final residue was triturated with methanol to give 6-(4-methyl-1-piperazinyl)-5H-dibenz[b,g]oxocine. M.P. 127° C.

Workup

  1. customremoved via a Dean and Stark trap
  2. customThe reaction mixture was then evaporated to dryness
  3. additionthe product re-treated
  4. customThe final residue was triturated with methanol

Sources & evidence

ORD record
ord-2931149e50aa45a3990fb8c0c7eadadd
Source dataset
uspto-grants-1990_02
Patent number
US04904688

Reaction notes

Loading…