Acetonitrile → 6-Bromo-4-((tetrahydro-2H-pyran-4-yl)methyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

HRID 1200354Notes

Reaction equation

HRID 1200354 reaction equation
[Br:1][c:2]1[c:3]([NH:9][C:10]([CH2:11][I:12])=[O:13])[n:4][cH:5][c:6]([Br:8])[n:7]1.[CH3:31][C:32]#[N:33].[CH:22]([N:23]([CH:24]([CH3:25])[CH3:26])[CH2:27][CH3:28])([CH3:29])[CH3:30].[O:14]1[CH2:15][CH2:16][CH:17]([CH2:20][NH2:21])[CH2:18][CH2:19]1>>[c:2]12[c:3]([n:4][cH:5][c:6]([Br:8])[n:7]1)[NH:9][C:10](=[O:13])[CH2:11][N:21]2[CH2:20][CH:17]1[CH2:16][CH2:15][O:14][CH2:19][CH2:18]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 81531DiisopropylethylamineHCID 27732104-AminomethyltetrahydropyranHCID 58298325N-(3,5-dibromopyrazin-2-yl)-2-iodoacetamide

Product 1

HCID 715670846-Bromo-4-((tetrahydro-2H-pyran-4-yl)methyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

Sources & evidence

ORD record
ord-07dd96ea859e43b3a556c2a41f2bc940
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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