Phosphorus oxychloride → 4-[4-(4-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)piperazin-1-yl]phenol

HRID 1200955Notes

Reaction equation

HRID 1200955 reaction equation
[OH:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH2:10][N:11]([c:14]3[n:15][c:16]([OH:23])[c:17]4[c:18]([n:19]3)[CH2:20][CH2:21][S:22]4)[CH2:12][CH2:13]2)[cH:6][cH:7]1.[P:24]([Cl:25])([Cl:26])([Cl:27])=[O:28]>>[OH:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH2:10][N:11]([c:14]3[n:15][c:16]([Cl:26])[c:17]4[c:18]([n:19]3)[CH2:20][CH2:21][S:22]4)[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 1785162312-[4-(4-hydroxyphenyl)piperazin-1-yl]-6,7-dihydro-1H-thieno[3,2-d]pyrimidin-4-one

Product 1

HCID 866162784-[4-(4-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)piperazin-1-yl]phenol

Sources & evidence

ORD record
ord-a8ba86fdea7b46e0888835d4ab7fae6c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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