Dimethylformamide → 1-methyl-6-{4-[3-(3-oxo-piperazin-1-yl)-propyl]-3-trifluoromethyl-phenyl}-1H-imidazo[4,5-c]pyridine-4-carbonitrile

HRID 1201691Notes

Reaction equation

HRID 1201691 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][c:5]1[c:6]([C:23]([F:24])([F:25])[F:26])[cH:7][c:8](-[c:11]2[cH:12][c:13]3[c:14]([c:15]([C:17]#[N:18])[n:16]2)[n:19][cH:20][n:21]3[CH3:22])[cH:9][cH:10]1.[O:27]=[C:28]1[NH:29][CH2:30][CH2:31][NH:32][CH2:33]1.[O:34]=[CH:35][N:36]([CH3:37])[CH3:38]>>[CH2:2]([CH2:3][CH2:4][c:5]1[c:6]([C:23]([F:24])([F:25])[F:26])[cH:7][c:8](-[c:11]2[cH:12][c:13]3[c:14]([c:15]([C:17]#[N:18])[n:16]2)[n:19][cH:20][n:21]3[CH3:22])[cH:9][cH:10]1)[N:32]1[CH2:31][CH2:30][NH:29][C:28](=[O:27])[CH2:33]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 231360Piperazin-2-oneHCID 576575506-(4-(3-bromopropyl)-3-(trifluoromethyl)-phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile

Product 1

HCID 576575571-methyl-6-{4-[3-(3-oxo-piperazin-1-yl)-propyl]-3-trifluoromethyl-phenyl}-1H-imidazo[4,5-c]pyridine-4-carbonitrile

Sources & evidence

ORD record
ord-6abc923c0c6a433ab48641bee254c9aa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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