反应详情

温度

0 °C

The compound of Example 6A (300 mg) is dissolved in methanol (3 ml) and cooled to 0° C. Trimethylsilyl chloride (590 mg, 4.7 eq.) is added dropwise in the course of 30 min. and the mixture is warmed to RT overnight. The volatile components are removed on a Rotavapor and subsequently under high vacuum. The target compound (224 mg, 92% of th.) is obtained.

1. temperaturethe mixture is warmed to RT overnight
2. customThe volatile components are removed on a Rotavapor and subsequently under high vacuum
3. customThe target compound (224 mg, 92% of th.) is obtained